Prince Frederik of Luxembourg, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, has died after a lifelong battle with a rare genetic disorder known as POLG mitochondrial disease. He was 22
Frederik d!ed in Paris on March 1, his family announced in a statement on the website of the POLG Foundation, which Frederik founded in 2022. “One light was extinguished, but so many remain,” his father said in the statement.
POLG is a “genetic mitochondrial disorder that robs the body’s cells of energy, in turn causing progressive multiple organ dysfunction and failure,” according to the foundation’s website.
Frederik was diagnosed with POLG at age 14, the family said. Because the disease causes such a wide range of symptoms and affects many different organ systems, it can be difficult to diagnose.
The prince d!ed a day after Rare Disease Day, an international day of awareness for rare diseases. An estimated 300 million people live with a rare disease.
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